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http://purl.uniprot.org/citations/23714241http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23714241http://www.w3.org/2000/01/rdf-schema#comment"A previous study using a mouse model of depression showed that chronic immobilization stress (CIS) reduces levels of insulin-like growth factor (IGF)-2, IGF binding protein 2 (IGFBP2), osteoglycin, and fibromodulin in the amygdala. Here, using human neuroblastoma cells, we tested whether these four proteins cooperatively modulate neuronal plasticity. We found that IGF-2 and IGFBP2 synergistically increased neurite outgrowth via enhanced early signaling through the IGF type 1 receptor. Furthermore, we found that osteoglycin, a small leucine-rich proteoglycan, significantly increased IGF-2/IGFPB2-induced neurite outgrowth, but fibromodulin had no effect. We also found that central amygdala neurons of CIS-induced depressive mouse showed a decreased total dendritic length. These findings suggest that CIS-responsive proteins modulate neuronal morphology during chronic stress."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.org/dc/terms/identifier"doi:10.1016/j.neulet.2013.05.038"xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Kim H.J."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Kim S."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Lee D.H."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Son H."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Kim G."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Jung S."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Kang S.S."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Cho G.J."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Choi W.S."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Jeong E.Y."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/author"Roh G.S."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/name"Neurosci Lett"xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/pages"249-254"xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/title"Enhancement of IGF-2-induced neurite outgrowth by IGF-binding protein-2 and osteoglycin in SH-SY5Y human neuroblastoma cells."xsd:string
http://purl.uniprot.org/citations/23714241http://purl.uniprot.org/core/volume"548"xsd:string
http://purl.uniprot.org/citations/23714241http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23714241
http://purl.uniprot.org/citations/23714241http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23714241
http://purl.uniprot.org/uniprot/#_A8K0R3-mappedCitation-23714241http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23714241
http://purl.uniprot.org/uniprot/#_B4DI63-mappedCitation-23714241http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23714241
http://purl.uniprot.org/uniprot/#_B2MUX6-mappedCitation-23714241http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23714241
http://purl.uniprot.org/uniprot/#_E3UN46-mappedCitation-23714241http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23714241