| http://purl.uniprot.org/citations/23715268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23715268 | http://www.w3.org/2000/01/rdf-schema#comment | "CD25, the alpha chain of the interleukin-2 receptor, is expressed in activated T cells and has a significant role in autoimmune disease and tumorigenesis; however, the mechanisms regulating transcription of CD25 remain elusive. Here we identify the Src-associated substrate during mitosis of 68 kDa (Sam68) as a novel non-Rel component in the nuclear factor-kappaB (NF-κB) complex that confers CD25 transcription. Our results demonstrate that Sam68 has an essential role in the induction and maintenance of CD25 in T cells. T-cell receptor engagement triggers translocation of the inhibitor of NF-κB kinase alpha (IKKα) from the cytoplasm to the nucleus, where it phosphorylates Sam68, causing complex formation with NF-κB in the nucleus. These findings reveal the important roles of KH domain-containing components and their spatial interactions with IKKs in determining the binding targets of NF-κB complexes, thus shedding novel insights into the regulatory specificity of NF-κB."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2916"xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Zheng W."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Richard S."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Hodgson A."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Wan F."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Fu K."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Tran D.Q."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/author | "Wier E.M."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/pages | "1909"xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/title | "Sam68 modulates the promoter specificity of NF-kappaB and mediates expression of CD25 in activated T cells."xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/23715268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23715268 |
| http://purl.uniprot.org/citations/23715268 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23715268 |
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| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-23715268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23715268 |
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| http://purl.uniprot.org/uniprot/#_B4DDX2-mappedCitation-23715268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23715268 |
| http://purl.uniprot.org/uniprot/#_B4E043-mappedCitation-23715268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23715268 |
| http://purl.uniprot.org/uniprot/#_O15163-mappedCitation-23715268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23715268 |