| http://purl.uniprot.org/citations/23723239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23723239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23723239 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosome segregation during mitosis requires assembly of the kinetochore complex at the centromere. Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centromere protein C (CENP-C). We have defined the determinants of this recognition mechanism and discovered that CENP-C binds a hydrophobic region in the CENP-A tail and docks onto the acidic patch of histone H2A and H2B. We further found that the more broadly conserved CENP-C motif uses the same mechanism for CENP-A nucleosome recognition. Our findings reveal a conserved mechanism for protein recruitment to centromeres and a histone recognition mode whereby a disordered peptide binds the histone tail through hydrophobic interactions facilitated by nucleosome docking."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1235532"xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1235532"xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Bai Y."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Jiang J."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Ghirlando R."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Xiao T.S."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Xiao T.S."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Straight A.F."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Straight A.F."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Zhou B.R."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Zhou B.R."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Rozendaal M."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/author | "Rozendaal M."xsd:string |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23723239 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |