| http://purl.uniprot.org/citations/23725765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23725765 | http://www.w3.org/2000/01/rdf-schema#comment | "Atria and ventricles exhibit distinct molecular profiles that produce structural and functional differences between the two cardiac compartments. However, the factors that determine these differences remain largely undefined. Cardiomyocyte-specific COUP-TFII ablation produces ventricularized atria that exhibit ventricle-like action potentials, increased cardiomyocyte size, and development of extensive T tubules. Changes in atrial characteristics are accompanied by alterations of 2,584 genes, of which 81% were differentially expressed between atria and ventricles, suggesting that a major function of myocardial COUP-TFII is to determine atrial identity. Chromatin immunoprecipitation assays using E13.5 atria identified classic atrial-ventricular identity genes Tbx5, Hey2, Irx4, MLC2v, MLC2a, and MLC1a, among many other cardiac genes, as potential COUP-TFII direct targets. Collectively, our results reveal that COUP-TFII confers atrial identity through direct binding and by modulating expression of a broad spectrum of genes that have an impact on atrial development and function."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.04.017"xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Chen W."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Tsai S.J."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Cheng C.M."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Wu S.P."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Lanz R.B."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Tsai S.Y."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Tsai M.J."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Ather S."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Wehrens X.H."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/author | "Respress J.L."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/pages | "417-426"xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/title | "Atrial identity is determined by a COUP-TFII regulatory network."xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23725765 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23725765 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YUZ8-mappedCitation-23725765 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23725765 |