| http://purl.uniprot.org/citations/23726901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23726901 | http://www.w3.org/2000/01/rdf-schema#comment | "Accurate and efficient gene expression requires that protein translation initiates from mRNA transcripts with high fidelity. At the same time, indiscriminate initiation of translation from multiple ATG start-sites per transcript has been demonstrated, raising fundamental questions regarding the rate and rationale governing alternative translation initiation. We devised a sensitive fluorescent reporter assay for monitoring alternative translation initiation. To demonstrate it, we map the translation initiation landscape of a Saccharomyces cerevisiae gene (RMD1) with a typical ATG sequence context profile. We found that up to 3%-5% of translation initiation events occur from alternative out-of-frame start codons downstream of the main ATG. Initiation from these codons follows the ribosome scanning model: initiation rates from different start sites are determined by ATG order, rather than their context strength. Genomic analysis of S. cerevisiae further supports the scanning model: ATG codons downstream rather than upstream of the main ATG tend to have higher context scores."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygeno.2013.05.003"xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/author | "Shapiro E."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/author | "Marx T."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/author | "Tuller T."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/author | "Zur H."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/author | "Ben-Yehezkel T."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/pages | "419-429"xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/title | "Mapping the translation initiation landscape of an S. cerevisiae gene using fluorescent proteins."xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/23726901 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23726901 |
| http://purl.uniprot.org/citations/23726901 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23726901 |
| http://purl.uniprot.org/uniprot/#_Q03441-mappedCitation-23726901 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23726901 |
| http://purl.uniprot.org/uniprot/Q03441 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23726901 |