| http://purl.uniprot.org/citations/23727585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23727585 | http://www.w3.org/2000/01/rdf-schema#comment | "Thrombocytopenia caused by rapid platelet consumption contributes to the severe thrombocytopenia of Wiskott-Aldrich syndrome (WAS) and to the milder thrombocytopenia seen in murine WAS. We show that rapid clearance of ¹¹¹In-labeled murine WASP(-) platelets correlates with enhanced splenic uptake. Using platelets labeled with a pH-sensitive fluorescent marker (pHrodo), we quantify normal platelet uptake by red pulp macrophages (RPMs), and demonstrate its enhancement after in vivo opsonization of platelets. The spleens of WASP(-) mice contain an increased number of RPM, and rapid clearance of WASP(-) platelets in WASP(-) mice in turn generates an increased number of pHrodo(+) splenic RPMs. To separately assess the platelet intrinsic and recipient-dependent functions involved in the clearance and splenic phagocyte uptake of WASP(-) platelets, we performed "crossed" pHrodo(+) platelet injection studies (wild type [WT] to WASP(-), WASP(-) to WT). We show that an extrinsic effect of recipient WASP deficiency on the clearance of WASP(-) platelets correlates with increased platelet uptake by RPMs. An intrinsic effect of platelet WASP deficiency on platelet clearance does not, however, correlate with increased total uptake by WT or WASP(-) RPMs. In contrast to other published findings, we find no evidence of a baseline or antibody-induced increase in phosphatidyl serine exposure on WASP(-) platelets. Our findings suggest that an increased number of RPMs in WASP(-) mice contributes significantly to the increased platelet consumption rate in WASP(-) mice. This might explain the consistent efficacy of splenectomy in murine and clinical WAS."xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.exphem.2013.05.003"xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/author | "Strom T.S."xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/author | "Prislovsky A."xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/name | "Exp Hematol"xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/pages | "789-798"xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/title | "Increased uptake by splenic red pulp macrophages contributes to rapid platelet turnover in WASP(-) mice."xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/23727585 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23727585 |
| http://purl.uniprot.org/citations/23727585 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23727585 |
| http://purl.uniprot.org/uniprot/#_Q53WY0-mappedCitation-23727585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23727585 |
| http://purl.uniprot.org/uniprot/#_P70315-mappedCitation-23727585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23727585 |
| http://purl.uniprot.org/uniprot/#_Q61078-mappedCitation-23727585 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23727585 |
| http://purl.uniprot.org/uniprot/Q61078 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23727585 |
| http://purl.uniprot.org/uniprot/P70315 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23727585 |
| http://purl.uniprot.org/uniprot/Q53WY0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23727585 |