| http://purl.uniprot.org/citations/23729330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23729330 | http://www.w3.org/2000/01/rdf-schema#comment | "Levels of caveolin-1 (Cav-1) in tumour epithelial cells increase during prostate cancer progression. Conversely, Cav-1 expression in the stroma can decline in advanced and metastatic prostate cancer. In a large cohort of 724 prostate cancers, we observed significantly decreased levels of stromal Cav-1 in concordance with increased Gleason score (p = 0.012). Importantly, reduced expression of Cav-1 in the stroma correlated with reduced relapse-free survival (p = 0.009), suggesting a role for stromal Cav-1 in inhibiting advanced disease. Silencing of Cav-1 by shRNA in WPMY-1 prostate fibroblasts resulted in up-regulation of Akt phosphorylation, and significantly altered expression of genes involved in angiogenesis, invasion, and metastasis, including a > 2.5-fold increase in TGF-β1 and γ-synuclein (SNCG) gene expression. Moreover, silencing of Cav-1 induced migration of prostate cancer cells when stromal cells were used as attractants. Pharmacological inhibition of Akt caused down-regulation of TGF-β1 and SNCG, suggesting that loss of Cav-1 in the stroma can influence Akt-mediated signalling in the tumour microenvironment. Cav-1-depleted stromal cells exhibited increased levels of intracellular cholesterol, a precursor for androgen biosynthesis, steroidogenic enzymes, and testosterone. These findings suggest that loss of Cav-1 in the tumour microenvironment contributes to the metastatic behaviour of tumour cells by a mechanism that involves up-regulation of TGF-β1 and SNCG through Akt activation. They also suggest that intracrine production of androgens, a process relevant to castration resistance, may occur in the stroma."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.org/dc/terms/identifier | "doi:10.1002/path.4217"xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Li R."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Lisanti M.P."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Freeman M.R."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "You S."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Adam R.M."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Danza G."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Rosati F."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Frolov A."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Thompson T.C."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Bartolucci G."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Ayala G."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Morello M."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/author | "Vizio D.D."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/name | "J Pathol"xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/pages | "77-87"xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/title | "Loss of caveolin-1 in prostate cancer stroma correlates with reduced relapse-free survival and is functionally relevant to tumour progression."xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://purl.uniprot.org/core/volume | "231"xsd:string |
| http://purl.uniprot.org/citations/23729330 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23729330 |
| http://purl.uniprot.org/citations/23729330 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23729330 |
| http://purl.uniprot.org/uniprot/#_D3Z0J2-mappedCitation-23729330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23729330 |
| http://purl.uniprot.org/uniprot/#_D3Z148-mappedCitation-23729330 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23729330 |