| http://purl.uniprot.org/citations/23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23731732 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination (HR) is essential for maintaining genomic integrity, which is challenged by a wide variety of potentially lethal DNA lesions. Regardless of the damage type, recombination is known to proceed by RAD51-mediated D-loop formation, followed by DNA repair synthesis. Nevertheless, the participating polymerases and extension mechanism are not well characterized. Here, we present a reconstitution of this step using purified human proteins. In addition to Pol δ, TLS polymerases, including Pol η and Pol κ, also can extend D-loops. In vivo characterization reveals that Pol η and Pol κ are involved in redundant pathways for HR. In addition, the presence of PCNA on the D-loop regulates the length of the extension tracks by recruiting various polymerases and might present a regulatory point for the various recombination outcomes."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2013.05.001"xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Haracska L."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Lee M.Y."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Burkovics P."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Krejci L."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Juhasz S."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Sebesta M."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/author | "Szabo J.E."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/name | "DNA Repair (Amst)"xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/pages | "691-698"xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/title | "Role of PCNA and TLS polymerases in D-loop extension during homologous recombination in humans."xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/23731732 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23731732 |
| http://purl.uniprot.org/citations/23731732 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23731732 |
| http://purl.uniprot.org/uniprot/#_P54132-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_Q07864-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_Q14191-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_Q15054-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_B7ZA36-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_B4DG64-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |
| http://purl.uniprot.org/uniprot/#_B3KN75-mappedCitation-23731732 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23731732 |