| http://purl.uniprot.org/citations/23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23732542 | http://www.w3.org/2000/01/rdf-schema#comment | "SNAP-25 is a key component of the synaptic-vesicle fusion machinery, involved in several psychiatric diseases including schizophrenia and ADHD. SNAP-25 protein expression is lower in different brain areas of schizophrenic patients and in ADHD mouse models. How the reduced expression of SNAP-25 alters the properties of synaptic transmission, leading to a pathological phenotype, is unknown. We show that, unexpectedly, halved SNAP-25 levels at 13-14 DIV not only fail to impair synaptic transmission but instead enhance evoked glutamatergic neurotransmission. This effect is possibly dependent on presynaptic voltage-gated calcium channel activity and is not accompanied by changes in spontaneous quantal events or in the pool of readily releasable synaptic vesicles. Notably, synapses of 13-14 DIV neurons with reduced SNAP-25 expression show paired-pulse depression as opposed to paired-pulse facilitation occurring in their wild-type counterparts. This phenotype disappears with synapse maturation. As alterations in short-term plasticity represent a new mechanism contributing to cognitive impairments in intellectual disabilities, our data provide mechanistic clues for neuronal circuit alterations in psychiatric diseases characterized by reduced expression of SNAP-25."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2013.75"xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Fossati G."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Bacci A."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Matteoli M."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Menna E."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Verderio C."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Antonucci F."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Pozzi D."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Corradini I."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Morini R."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/author | "Pacioni S."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/pages | "645-651"xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/title | "Reduced SNAP-25 alters short-term plasticity at developing glutamatergic synapses."xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23732542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23732542 |
| http://purl.uniprot.org/citations/23732542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23732542 |
| http://purl.uniprot.org/uniprot/#_A6HQK1-mappedCitation-23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23732542 |
| http://purl.uniprot.org/uniprot/#_A6HQK2-mappedCitation-23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23732542 |
| http://purl.uniprot.org/uniprot/#_A6HQK3-mappedCitation-23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23732542 |
| http://purl.uniprot.org/uniprot/#_Q2XTA5-mappedCitation-23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23732542 |
| http://purl.uniprot.org/uniprot/#_P60879-mappedCitation-23732542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23732542 |