| http://purl.uniprot.org/citations/23733751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23733751 | http://www.w3.org/2000/01/rdf-schema#comment | "Metastatic breast cancer remains the chief cause of cancer-related death among women in the Western world. Although loss of cell-cell adhesion is key to breast cancer progression, little is known about the underlying mechanisms that drive tumor invasion and metastasis. Here, we show that somatic loss of p120-catenin (p120) in a conditional mouse model of noninvasive mammary carcinoma results in formation of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes. Loss of p120 in anchorage-dependent breast cancer cell lines strongly promoted anoikis resistance through hypersensitization of growth factor receptor (GFR) signaling. Interestingly, p120 deletion also induced secretion of inflammatory cytokines, a feature that likely underlies the formation of the prometastatic microenvironment in p120-negative mammary carcinomas. Our results establish a preclinical platform to develop tailored intervention regimens that target GFR signals to treat p120-negative metastatic breast cancers."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-13-0180"xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Jonkers J."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Vermeulen J.F."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "van Diest P.J."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "van der Wall E."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Peeters T."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "van der Groep P."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Derksen P.W."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Schackmann R.C."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Braumuller T.M."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Vlug E.J."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "van Amersfoort M."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Klarenbeek S."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Stelloo S."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/author | "Tenhagen M."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/pages | "4937-4949"xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/title | "Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/23733751 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23733751 |
| http://purl.uniprot.org/citations/23733751 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23733751 |
| http://purl.uniprot.org/uniprot/#_E9Q8Z5-mappedCitation-23733751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23733751 |