| http://purl.uniprot.org/citations/23739639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23739639 | http://www.w3.org/2000/01/rdf-schema#comment | "Herpes simplex virus type 1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by herpes simplex virus type 1 and functions together with heparan sulphate proteoglycans to mediate adsorption to epithelial cells. Ligands of MARCO dramatically inhibit herpes simplex virus type 1 adsorption and infection of human keratinocytes and protect mice against infection. Herpes simplex virus type 1 glycoprotein C closely co-localizes with MARCO at the cell surface, and glycoprotein C binds directly to purified MARCO with high affinity. Increasing MARCO expression enhances herpes simplex virus type 1 infection while MARCO(-/-) mice have reduced susceptibility to infection by herpes simplex virus type 1. These findings demonstrate that herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of herpes simplex virus type 1 in skin infection."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2963"xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/author | "Yamasaki K."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/author | "Kobzik L."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/author | "Gallo R.L."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/author | "Nakatsuji T."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/author | "MacLeod D.T."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/pages | "1963"xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/title | "HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection."xsd:string |
| http://purl.uniprot.org/citations/23739639 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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