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http://purl.uniprot.org/citations/23742758http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23742758http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

Cathepsin S (Cat S) protein expression is increased in human abdominal aortic aneurysm (AAA) lesions and Cat S has been suggested a direct role by promoting inflammatory response partly in experimental AAA. The purpose of this study is to observe the expression of serum Cat S and hs-CRP and its clinical significance in AAA patients.

Design and methods

We collected serum samples from 31 AAA patients and 32 controls. Cat S and hs-CRP levels were measured by a sandwich-type enzyme-linked immunosorbent assay (ELISA) and an enhanced immunoturbidimetric assay respectively. The maximum diameter of the AAA was identified by ultrasonography.

Results

The patients with AAA had higher serum Cat S and hs-CRP levels than the controls (p<0.05). Furthermore, human serum Cat S levels were strongly correlated with hs-CRP by the nonparametric Spearman correlation tests (B=0.849, p<0.05). Based on Pearson's correlation test, human serum Cat S and hs-CRP levels were positively correlated with AAA diameter size (p<0.05). Cat S was correlated independently with the hs-CRP in all subjects (p<0.01). After adjustment for the maximum diameter of the abdominal aorta-associated variables, Cat S combined hs-CRP (R(2)=0.801) is better than Cat S (R(2)=0.740) in predicting the maximum diameter of AAA lesions.

Conclusion

Combined serum Cat S and hs-CRP levels are better in predicting the inflammatory activity of AAA lesions in the clinical setting."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.org/dc/terms/identifier"doi:10.1016/j.clinbiochem.2013.05.065"xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Chen Z."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Du J."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Cao X."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Liu J."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Liu R."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Wang M."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Zhang H."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Yang Y."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Yang Y.'"xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Qin Y."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/author"Liu O."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/name"Clin Biochem"xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/pages"1026-1029"xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/title"Combined Cathepsin S and hs-CRP predicting inflammation of abdominal aortic aneurysm."xsd:string
http://purl.uniprot.org/citations/23742758http://purl.uniprot.org/core/volume"46"xsd:string
http://purl.uniprot.org/citations/23742758http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23742758
http://purl.uniprot.org/citations/23742758http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23742758
http://purl.uniprot.org/uniprot/#_A0A7P0TB77-mappedCitation-23742758http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23742758
http://purl.uniprot.org/uniprot/#_C9JRE9-mappedCitation-23742758http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23742758
http://purl.uniprot.org/uniprot/#_P02741-mappedCitation-23742758http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23742758
http://purl.uniprot.org/uniprot/#_P25774-mappedCitation-23742758http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23742758
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