| http://purl.uniprot.org/citations/23744080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23744080 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-34 (IL-34) is highly expressed in brain. IL-34 signaling via its cognate receptor, colony-stimulating factor-1 receptor (CSF-1R), is required for the development of microglia. However, the differential expression of IL-34 and the CSF-1R in brain suggests that IL-34 may signal via an alternate receptor. By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified receptor-type protein-tyrosine phosphatase ζ (PTP-ζ), a cell surface chondroitin sulfate (CS) proteoglycan, as a novel IL-34 receptor. PTP-ζ is primarily expressed on neural progenitors and glial cells and is highly expressed in human glioblastomas. IL-34 selectively bound PTP-ζ in CSF-1R-deficient U251 human glioblastoma cell lysates and inhibited the proliferation, clonogenicity, and motility of U251 cells in a PTP-ζ-dependent manner. These effects were correlated with an increase in tyrosine phosphorylation of the previously identified PTP-ζ downstream effectors focal adhesion kinase and paxillin. IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-ζ and to the cells, indicating a dependence of binding on PTP-ζ CS moieties. This study identifies an alternate receptor for IL-34 that may mediate its action on novel cellular targets."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.442731"xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Nieves E."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Halenbeck R."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Hsu A.W."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Cheng H.Y."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Nandi S."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Stanley E.R."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Yeung Y.G."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Mehler M.F."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Cioce M."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Gokhan S."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/author | "Tesfa L."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/pages | "21972-21986"xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/title | "Receptor-type protein-tyrosine phosphatase zeta is a functional receptor for interleukin-34."xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23744080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23744080 |
| http://purl.uniprot.org/citations/23744080 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23744080 |
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| http://purl.uniprot.org/uniprot/#_A0A0A6YWY3-mappedCitation-23744080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23744080 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVD2-mappedCitation-23744080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23744080 |