| http://purl.uniprot.org/citations/23746980 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23746980 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor. hESC-derived endoderm cells do not express KDR but, when cultured in media supporting hepatic differentiation, generate KDR+ hepatic progenitors and KDR-hepatic cells. KDR+ progenitors require active KDR signaling both to instruct their own differentiation into hepatic cells and to non-cell-autonomously support the functional maturation of cocultured KDR-hepatic cells. Analysis of human fetal livers suggests that similar progenitors are present in human livers. Lineage tracing in mice provides in vivo evidence of a KDR+ hepatic progenitor for fetal hepatoblasts, adult hepatocytes, and adult cholangiocytes. Altogether, our findings reveal that KDR is a conserved marker for endoderm-derived hepatic progenitors and a functional receptor instructing early liver development."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2013.04.026"xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Evans T."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Han S."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Goldman O."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Jacobs A."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Evans M.J."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Sourisseau M."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "D'Souza S."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Corneo B."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Kotton D.N."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Gouon-Evans V."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Kalir T."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Dziedzic N."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Hamou W."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Bissig K.D."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/author | "Sourrisseau M."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/pages | "748-760"xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/title | "KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development."xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/23746980 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23746980 |