| http://purl.uniprot.org/citations/23764004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23764004 | http://www.w3.org/2000/01/rdf-schema#comment | "B cell receptor (BCR) signaling pathway components represent promising treatment targets in diffuse large B cell lymphoma (DLBCL) and additional B cell tumors. BCR signaling activates spleen tyrosine kinase (SYK) and downstream pathways including PI3K/AKT and NF-κB. In previous studies, chemical SYK blockade selectively decreased BCR signaling and induced apoptosis of BCR-dependent DLBCLs. Herein, we characterize distinct SYK/PI3K-dependent survival pathways in DLBCLs with high or low baseline NF-κB activity including selective repression of the pro-apoptotic HRK protein in NF-κB-low tumors. We also define SYK/PI3K-dependent cholesterol biosynthesis as a feed-forward mechanism of maintaining the integrity of BCRs in lipid rafts in DLBCLs with low or high NF-κB. In addition, SYK amplification and PTEN deletion are identified as selective genetic alterations in primary "BCR"-type DLBCLs."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.05.002"xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Ouyang J."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Monti S."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Kutok J.L."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Neuberg D."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Dogan A."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Chapuy B."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Doench J.G."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Juszczynski P."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Shipp M.A."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Rodig S.J."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Golub T."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Witzig T.E."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Habermann T.M."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/author | "Bogusz A.M."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/pages | "826-838"xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/title | "SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/23764004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23764004 |
| http://purl.uniprot.org/citations/23764004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23764004 |