| http://purl.uniprot.org/citations/23770887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23770887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23770887 | http://www.w3.org/2000/01/rdf-schema#comment | "Parkin is a RING-between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates, and mutations in Parkin are linked to Parkinson's disease, cancer and mycobacterial infection. The RING-between-RING family of E3 ligases are suggested to function with a canonical RING domain and a catalytic cysteine residue usually restricted to HECT E3 ligases, thus termed 'RING/HECT hybrid' enzymes. Here we present the 1.58 Å structure of Parkin-R0RBR, revealing the fold architecture for the four RING domains, and several unpredicted interfaces. Examination of the Parkin active site suggests a catalytic network consisting of C431 and H433. In cells, mutation of C431 eliminates Parkin-catalysed degradation of mitochondria, and capture of an ubiquitin oxyester confirms C431 as Parkin's cellular active site. Our data confirm that Parkin is a RING/HECT hybrid, and provide the first crystal structure of an RING-between-RING E3 ligase at atomic resolution, providing insight into this disease-related protein."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2982"xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms2982"xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Baker J."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Baker J."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Nguyen L."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Nguyen L."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Walker D."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Walker D."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Yao N."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Yao N."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Diep L."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Diep L."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Johnston J.A."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Lougheed J.C."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Lougheed J.C."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Chiou S."xsd:string |
| http://purl.uniprot.org/citations/23770887 | http://purl.uniprot.org/core/author | "Chiou S."xsd:string |