| http://purl.uniprot.org/citations/23772037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23772037 | http://www.w3.org/2000/01/rdf-schema#comment | "The activation, differentiation, and subsequent effector functions of CD4 T cells depend on interactions with a multitude of MHC class II (MHCII)-expressing APCs. To evaluate the individual contribution of various APCs to CD4 T cell function, we have designed a new murine tool for selective in vivo expression of MHCII in subsets of APCs. Conditional expression of MHCII in B cells was achieved using a cre-loxP approach. After i.v. or s.c. priming, partial proliferation and activation of CD4 T cells was observed in mice expressing MHCII only by B cells. Restricting MHCII expression to B cells constrained secondary CD4 T cell responses in vivo, as demonstrated in a CD4 T cell-dependent model of autoimmunity, experimental autoimmune encephalomyelitis. These results highlight the limitations of B cell Ag presentation during initiation and propagation of CD4 T cell function in vivo using a novel system to study individual APCs by the conditional expression of MHCII."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1201598"xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Chen P."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Carrero J.A."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Ding H."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Raabe T."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Sim J."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Dragatsis I."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Allenspach E.J."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Wu G.F."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Laufer T.M."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Archambault A.S."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Barnett L.G."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "McGee N.G."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/author | "Wright J.O."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/pages | "545-550"xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/title | "Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses."xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/23772037 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23772037 |
| http://purl.uniprot.org/citations/23772037 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23772037 |
| http://purl.uniprot.org/uniprot/#_A0A1D8M9B3-mappedCitation-23772037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23772037 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-23772037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23772037 |