| http://purl.uniprot.org/citations/23775115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23775115 | http://www.w3.org/2000/01/rdf-schema#comment | "C/EBPβ is an important regulator of oncogene-induced senescence (OIS). Here, we show that C/EBPγ, a heterodimeric partner of C/EBPβ whose biological functions are not well understood, inhibits cellular senescence. Cebpg(-/-) mouse embryonic fibroblasts (MEFs) proliferated poorly, entered senescence prematurely, and expressed a proinflammatory gene signature, including elevated levels of senescence-associated secretory phenotype (SASP) genes whose induction by oncogenic stress requires C/EBPβ. The senescence-suppressing activity of C/EBPγ required its ability to heterodimerize with C/EBPβ. Covalently linked C/EBPβ homodimers (β∼β) inhibited the proliferation and tumorigenicity of Ras(V12)-transformed NIH 3T3 cells, activated SASP gene expression, and recruited the CBP coactivator in a Ras-dependent manner, whereas γ∼β heterodimers lacked these capabilities and efficiently rescued proliferation of Cebpg(-/-) MEFs. C/EBPβ depletion partially restored growth of C/EBPγ-deficient cells, indicating that the increased levels of C/EBPβ homodimers in Cebpg(-/-) MEFs inhibit proliferation. The proliferative functions of C/EBPγ are not restricted to fibroblasts, as hematopoietic progenitors from Cebpg(-/-) bone marrow also displayed impaired growth. Furthermore, high CEBPG expression correlated with poorer clinical prognoses in several human cancers, and C/EBPγ depletion decreased proliferation and induced senescence in lung tumor cells. Our findings demonstrate that C/EBPγ neutralizes the cytostatic activity of C/EBPβ through heterodimerization, which prevents senescence and suppresses basal transcription of SASP genes."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01674-12"xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Lee S."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Thomas S."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Martin N."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Malik R."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Keller J.R."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Johnson P.F."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Alvord W.G."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Huggins C.J."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Olanich M.E."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Salotti J."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/author | "Quinones O.A."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/pages | "3242-3258"xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/title | "C/EBPgamma suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPbeta."xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23775115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23775115 |
| http://purl.uniprot.org/citations/23775115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23775115 |
| http://purl.uniprot.org/uniprot/#_P28033-mappedCitation-23775115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23775115 |
| http://purl.uniprot.org/uniprot/#_P53567-mappedCitation-23775115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23775115 |
| http://purl.uniprot.org/uniprot/#_P53568-mappedCitation-23775115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23775115 |
| http://purl.uniprot.org/uniprot/#_O70192-mappedCitation-23775115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23775115 |