| http://purl.uniprot.org/citations/23776170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23776170 | http://www.w3.org/2000/01/rdf-schema#comment | "We have generated a panel of transgenic mice expressing HLA-A*01:03, -A*24:02, -B*08:01, -B*27:05, -B*35:01, -B*44:02, or -C*07:01 as chimeric monochain molecules (i.e., appropriate HLA α1α2 H chain domains fused with a mouse α3 domain and covalently linked to human β2-microglobulin). Whereas surface expression of several transgenes was markedly reduced in recipient mice that coexpressed endogenous H-2 class I molecules, substantial surface expression of all human transgenes was observed in mice lacking H-2 class I molecules. In these HLA monochain transgenic/H-2 class I null mice, we observed a quantitative and qualitative restoration of the peripheral CD8(+) T cell repertoire, which exhibited a TCR diversity comparable with C57BL/6 WT mice. Potent epitope-specific, HLA-restricted, IFN-γ-producing CD8(+) T cell responses were generated against known reference T cell epitopes after either peptide or DNA immunization. HLA-wise, these new transgenic strains encompass a large proportion of individuals from all major human races and ethnicities. In combination with the previously created HLA-A*02:01 and -B*07:02 transgenic mice, the novel HLA transgenic mice described in this report should be a versatile preclinical animal model that will speed up the identification and optimization of HLA-restricted CD8(+) T cell epitopes of potential interest in various autoimmune human diseases and in preclinical evaluation of T cell-based vaccines."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300483"xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Lim A."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Rasmussen M."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Buus S."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Lemercier B."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Boucherma R."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Berard M."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Langa-Vives F."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Benmohamed L."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Bouziat R."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Kridane-Miledi H."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Gatard T."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/author | "Rooke R."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/pages | "583-593"xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/title | "HLA-A*01:03, HLA-A*24:02, HLA-B*08:01, HLA-B*27:05, HLA-B*35:01, HLA-B*44:02, and HLA-C*07:01 monochain transgenic/H-2 class I null mice: novel versatile preclinical models of human T cell responses."xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/23776170 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23776170 |
| http://purl.uniprot.org/citations/23776170 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23776170 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G3-mappedCitation-23776170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23776170 |
| http://purl.uniprot.org/uniprot/#_K7WBQ4-mappedCitation-23776170 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23776170 |