| http://purl.uniprot.org/citations/23776175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23776175 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23776175 | http://www.w3.org/2000/01/rdf-schema#comment | "Recognition of microbial products by TLRs is critical for mediating innate immune responses to invading pathogens. In this study, we identify a novel scaffold protein in TLR4 signaling called SAM and SH3 domain containing protein 1 (SASH1). Sash1 is expressed across all microvascular beds and functions as a scaffold molecule to independently bind TRAF6, TAK1, IκB kinase α, and IκB kinase β. This interaction fosters ubiquitination of TRAF6 and TAK1 and promotes LPS-induced NF-κB, JNK, and p38 activation, culminating in increased production of proinflammatory cytokines and increased LPS-induced endothelial migration. Our findings suggest that SASH1 acts to assemble a signaling complex downstream of TLR4 to activate early endothelial responses to receptor activation."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1200583"xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1200583"xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Park Y.J."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Park Y.J."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Veenstra T.D."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Veenstra T.D."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Karsan A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Karsan A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Clayton A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Clayton A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Blonder J."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Blonder J."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Fuller M.E."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Fuller M.E."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Dauphinee S.M."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Dauphinee S.M."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Hussainkhel A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/author | "Hussainkhel A."xsd:string |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23776175 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |