| http://purl.uniprot.org/citations/23782696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23782696 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23782696 | http://www.w3.org/2000/01/rdf-schema#comment | "Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties. We found that overexpression of BAI1 results in activation of the Rho pathway via a Gα(12/13)-dependent mechanism, with truncation of the BAI1 N terminus resulting in a dramatic enhancement in receptor signaling. This constitutive activity of the truncated BAI1 mutant also resulted in enhanced downstream phosphorylation of ERK as well as increased receptor association with β-arrestin2 and increased ubiquitination of the receptor. To gain insights into the regulation of BAI1 signaling, we screened the C terminus of BAI1 against a proteomic array of PDZ domains to identify novel interacting partners. These screens revealed that the BAI1 C terminus interacts with a variety of PDZ domains from synaptic proteins, including MAGI-3. Removal of the BAI1 PDZ-binding motif resulted in attenuation of receptor signaling to Rho but had no effect on ERK activation. Conversely, co-expression with MAGI-3 was found to potentiate signaling to ERK by constitutively active BAI1 in a manner that was dependent on the PDZ-binding motif of the receptor. Biochemical fractionation studies revealed that BAI1 is highly enriched in post-synaptic density fractions, a finding consistent with our observations that BAI1 can interact with PDZ proteins known to be concentrated in the post-synaptic density. These findings demonstrate that BAI1 is a synaptic receptor that can activate both the Rho and ERK pathways, with the N-terminal and C-terminal regions of the receptor playing key roles in the regulation of BAI1 signaling activity."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.489757"xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.489757"xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Stephenson J.R."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Stephenson J.R."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Hall R.A."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Hall R.A."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Van Meir E.G."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Van Meir E.G."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Kaur B."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Kaur B."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Paavola K.J."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Paavola K.J."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Schaefer S.A."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/author | "Schaefer S.A."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/pages | "22248-22256"xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/pages | "22248-22256"xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/title | "Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density."xsd:string |
| http://purl.uniprot.org/citations/23782696 | http://purl.uniprot.org/core/title | "Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density."xsd:string |