| http://purl.uniprot.org/citations/23784669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23784669 | http://www.w3.org/2000/01/rdf-schema#comment | "Following initial platelet activation, arachidonic acid is metabolised by cyclooxygenase-1 and 12-lipoxygenase (12-LOX). While the role of 12-LOX in the platelet is not well defined, recent evidence suggests that it may be important for regulation of platelet activity and is agonist-specific in the manner in which it regulates platelet function. Using small molecule inhibitors selective for 12-LOX and 12-LOX-deficient mice, the role of 12-LOX in regulation of human platelet activation and thrombosis was investigated. Pharmacologically inhibiting 12-LOX resulted in attenuation of platelet aggregation, selective inhibition of dense versus alpha granule secretion, and inhibition of platelet adhesion under flow for PAR4 and collagen. Additionally, 12-LOX-deficient mice showed attenuated integrin activity to PAR4-AP and convulxin compared to wild-type mice. Finally, platelet activation by PARs was shown to be differentially dependent on COX-1 and 12-LOX with PAR1 relying on COX-1 oxidation of arachidonic acid while PAR4 being more dependent on 12-LOX for normal platelet function. These studies demonstrate an important role for 12-LOX in regulating platelet activation and thrombosis. Furthermore, the data presented here provide a basis for potentially targeting 12-LOX as a means to attenuate unwanted platelet activation and clot formation."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.org/dc/terms/identifier | "doi:10.1160/th13-01-0014"xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Boutaud O."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Holinstat M."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Jadhav A."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Holman T.R."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Yeung J."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Maloney D.J."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Rai G."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Simeonov A."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Apopa P.L."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Vesci J."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Stolla M."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/author | "Fernandez-Perez P."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/pages | "569-581"xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/title | "12-lipoxygenase activity plays an important role in PAR4 and GPVI-mediated platelet reactivity."xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23784669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23784669 |
| http://purl.uniprot.org/citations/23784669 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23784669 |
| http://purl.uniprot.org/uniprot/#_A2CF85-mappedCitation-23784669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23784669 |
| http://purl.uniprot.org/uniprot/#_Q16120-mappedCitation-23784669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23784669 |
| http://purl.uniprot.org/uniprot/#_P18054-mappedCitation-23784669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23784669 |