| http://purl.uniprot.org/citations/23784775 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23784775 | http://www.w3.org/2000/01/rdf-schema#comment | "Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Thus, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics. Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, is overexpressed in TNBC, where it supports malignant growth, invasion, and metastasis largely through modulating epidermal growth factor receptor (EGFR). We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation and inactivation, leading to EGFR up-regulation. Thus, UBASH3B may function as a crucial node in bridging multiple invasion-promoting pathways, thereby providing a potential therapeutic target for TNBC."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1300873110"xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Guan P."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Kang Y."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Qiao Y."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Yu Q."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Wong C.H."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Huynh K."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Lee S.T."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Feng M."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Hoon D.S."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Tan E.Y."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/author | "Karuturi K.M."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/pages | "11121-11126"xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/title | "Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis."xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23784775 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23784775 |