| http://purl.uniprot.org/citations/23785285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23785285 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify new regulators of antiviral innate immunity, we completed the first genome-wide gene silencing screen assessing the transcriptional response at the interferon-β (IFNB1) promoter following Sendai virus (SeV) infection. We now report a novel link between WNT signaling pathway and the modulation of retinoic acid-inducible gene I (RIG-I)-like receptor (RLR)-dependent innate immune responses. Here we show that secretion of WNT2B and WNT9B and stabilization of β-catenin (CTNNB1) upon virus infection negatively regulate expression of representative inducible genes IFNB1, IFIT1 and TNF in a CTNNB1-dependent effector mechanism. The antiviral response is drastically reduced by glycogen synthase kinase 3 (GSK3) inhibitors but restored in CTNNB1 knockdown cells. The findings confirm a novel regulation of antiviral innate immunity by a canonical-like WNT/CTNNB1 signaling pathway. The study identifies novel avenues for broad-spectrum antiviral targets and preventing immune-mediated diseases upon viral infection."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1003416"xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Pham T."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Grandvaux N."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Chatel-Chaix L."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Lamarre D."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Cohen E."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Baril M."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Fink K."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Bilodeau M."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Raymond V.A."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Audette K."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Duchaine J."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Es-Saad S."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Guenier A.S."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/author | "Servant M."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/pages | "e1003416"xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/title | "Genome-wide RNAi screen reveals a new role of a WNT/CTNNB1 signaling pathway as negative regulator of virus-induced innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/23785285 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23785285 |
| http://purl.uniprot.org/citations/23785285 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23785285 |
| http://purl.uniprot.org/uniprot/#_B4DSW9-mappedCitation-23785285 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23785285 |