| http://purl.uniprot.org/citations/23785489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23785489 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) is associated with X-linked mental retardation and autism spectrum disorder. We found that IL1RAPL1 regulates synapse formation of cortical neurons. To investigate how IL1RAPL1 controls synapse formation, we here screened IL1RAPL1-interacting proteins by affinity chromatography and mass spectroscopy. IL1RAPL1 interacted with Mcf2-like (Mcf2l), a Rho guanine nucleotide exchange factor, through the cytoplasmic Toll/IL-1 receptor domain. Knockdown of endogenous Mcf2l and treatment with an inhibitor of Rho-associated protein kinase (ROCK), the downstream kinase of RhoA, suppressed IL1RAPL1-induced excitatory synapse formation of cortical neurons. Furthermore, we found that the expression of IL1RAPL1 affected the turnover of AMPA receptor subunits. Insertion of GluA1-containing AMPA receptors to the cell surface was decreased, whereas that of AMPA receptors composed of GluA2/3 was enhanced. Mcf2l knockdown and ROCK inhibitor treatment diminished the IL1RAPL1-induced changes of AMPA receptor subunit insertions. Our results suggest that Mcf2l-RhoA-ROCK signaling pathway mediates IL1RAPL1-dependent formation and stabilization of glutamatergic synapses of cortical neurons."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0066254"xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/author | "Taguchi R."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/author | "Mishina M."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/author | "Ra M."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/pages | "e66254"xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/title | "IL1RAPL1 associated with mental retardation and autism regulates the formation and stabilization of glutamatergic synapses of cortical neurons through RhoA signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23785489 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23785489 |
| http://purl.uniprot.org/citations/23785489 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23785489 |
| http://purl.uniprot.org/uniprot/#_Q0VDP7-mappedCitation-23785489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23785489 |
| http://purl.uniprot.org/uniprot/#_B1ASU0-mappedCitation-23785489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23785489 |
| http://purl.uniprot.org/uniprot/#_P59823-mappedCitation-23785489 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23785489 |
| http://purl.uniprot.org/uniprot/P59823 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23785489 |
| http://purl.uniprot.org/uniprot/B1ASU0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23785489 |
| http://purl.uniprot.org/uniprot/Q0VDP7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23785489 |