| http://purl.uniprot.org/citations/23789983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23789983 | http://www.w3.org/2000/01/rdf-schema#comment | "The interplay between vitamin D and IGF-I is complex and occurs at both endocrine and paracrine/autocrine levels. Vitamin D has been shown to increase circulating IGF-I and IGFBP-3, with the consistent finding of a positive correlation between vitamin D and IGF-I serum values in population-based cohorts of healthy subjects. The modulation of IGF-I and IGFBP-3 concentrations by vitamin D may impact recombinant human (rh) GH dosing for the treatment of GHD. It might also underlie some of the extra-skeletal beneficial effects ascribed to vitamin D. On the other hand, IGF-I stimulates renal production of 1,25-dihydroxyvitamin D, which increases calcium and phosphate availability in the body and suppresses PTH secretion. This effect is responsible for an altered calcium-phosphate balance in uncontrolled acromegaly and might also account for the improvement in bone metabolism associated with rhGH treatment in patients with GHD. Data on the paracrine/autocrine vitamin D-IGF-I interactions are abundant, but mostly not linked to one another. As a result, it is not possible to draw a comprehensive picture of the physiological and/or pathological interrelations between vitamin D, IGF-I and IGF-binding proteins (IGFBP) in different tissues. A potential role of vitamin D action is related to its association with carcinogenesis, a paradigm being breast cancer. Current evidence indicates that, in breast tumours, vitamin D modulates the IGF-I/IGFBP ratio to decrease proliferation and increase apoptosis."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.org/dc/terms/identifier | "doi:10.1111/cen.12268"xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Boschetti M."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Giusti A."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Ferone D."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Minuto F."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Ameri P."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/author | "Murialdo G."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/name | "Clin Endocrinol (Oxf)"xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/pages | "457-463"xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/title | "Interactions between vitamin D and IGF-I: from physiology to clinical practice."xsd:string |
| http://purl.uniprot.org/citations/23789983 | http://purl.uniprot.org/core/volume | "79"xsd:string |
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