| http://purl.uniprot.org/citations/23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23797873 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription of rRNA genes (rDNAs) in the nucleolus is regulated by epigenetic chromatin modifications including histone H3 lysine (de)methylation. Here we show that LegAS4, a Legionella pneumophila type IV secretion system (TFSS) effector, is targeted to specific rDNA chromatin regions in the host nucleolus. LegAS4 promotes rDNA transcription, through its SET-domain (named after Drosophila Su(var)3-9, enhancer of zeste [E(z)], and trithorax [trx]) histone lysine methyltransferase (HKMTase) activity. LegAS4's association with rDNA chromatin is mediated by interaction with host HP1α/γ. L. pneumophila infection potently activates rDNA transcription in a TFSS-dependent manner. Other bacteria, including Bordetella bronchiseptica and Burkholderia thailandensis, also harbour nucleolus-localized LegAS4-like HKMTase effectors. The B. thailandensis type III effector BtSET promotes H3K4 methylation of rDNA chromatin, contributing to infection-induced rDNA transcription and bacterial intracellular replication. Thus, activation of host rDNA transcription might be a general bacterial virulence strategy."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2013.86"xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Cai T."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Ge J."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Li T."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Kan B."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Lu Q."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/author | "Shao F."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/name | "EMBO Rep"xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/pages | "733-740"xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/title | "SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription."xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/23797873 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23797873 |
| http://purl.uniprot.org/citations/23797873 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23797873 |
| http://purl.uniprot.org/uniprot/#_A0A0H3LYM0-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |
| http://purl.uniprot.org/uniprot/#_Q13185-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |
| http://purl.uniprot.org/uniprot/#_Q5ZUS4-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |
| http://purl.uniprot.org/uniprot/#_P45973-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |
| http://purl.uniprot.org/uniprot/#_Q2STB6-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |
| http://purl.uniprot.org/uniprot/#_P06748-mappedCitation-23797873 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23797873 |