| http://purl.uniprot.org/citations/23797875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23797875 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23797875 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt/β-catenin signalling is central to development and its regulation is essential in preventing cancer. Using phosphorylation of Dishevelled as readout of pathway activation, we identified Drosophila Wnk kinase as a new regulator of canonical Wnt/β-catenin signalling. WNK kinases are known for regulating ion co-transporters associated with hypertension disorders. We demonstrate that wnk loss-of-function phenotypes resemble canonical Wnt pathway mutants, while Wnk overexpression causes gain-of-function canonical Wnt-signalling phenotypes. Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2013.88"xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.org/dc/terms/identifier | "doi:10.1038/embor.2013.88"xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Boutros M."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Serysheva E."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Serysheva E."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Demir K."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Demir K."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Jenny A."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Jenny A."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Grumolato L."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Grumolato L."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Aaronson S."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Aaronson S."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Balmer S."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Balmer S."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Berhane H."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Berhane H."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Bodak M."xsd:string |
| http://purl.uniprot.org/citations/23797875 | http://purl.uniprot.org/core/author | "Bodak M."xsd:string |