| http://purl.uniprot.org/citations/23806619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23806619 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23806619 | http://www.w3.org/2000/01/rdf-schema#comment | "LEM domain (LEM-D) proteins are components of an extensive protein network that assembles beneath the inner nuclear envelope. Defects in LEM-D proteins cause tissue-restricted human diseases associated with altered stem cell homeostasis. Otefin (Ote) is a Drosophila LEM-D protein that is intrinsically required for female germline stem cell (GSC) maintenance. Previous studies linked Ote loss with transcriptional activation of the key differentiation gene bag-of-marbles (bam), leading to the model in which Ote tethers the bam gene to the nuclear periphery for gene silencing. Using genetic and phenotypic analyses of multiple ote(-/-) backgrounds, we obtained evidence that is inconsistent with this model. We show that bam repression is maintained in ote(-/-) GSCs and that germ cell loss persists in ote(-/-), bam(-/-) mutants, together demonstrating that GSC loss is independent of bam transcription. We show that the primary defect in ote(-/-) GSCs is a block of differentiation, which ultimately leads to germ cell death."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.05.023"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2013.05.023"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Barton L.J."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Barton L.J."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Geyer P.K."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Geyer P.K."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Pinto B.S."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Pinto B.S."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Wallrath L.L."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/author | "Wallrath L.L."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/pages | "645-654"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/pages | "645-654"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/title | "The Drosophila nuclear lamina protein otefin is required for germline stem cell survival."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/title | "The Drosophila nuclear lamina protein otefin is required for germline stem cell survival."xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23806619 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23806619 |
| http://purl.uniprot.org/citations/23806619 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23806619 |