| http://purl.uniprot.org/citations/23806960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23806960 | http://www.w3.org/2000/01/rdf-schema#comment | "Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range extracellular signaling by endocannabinoids is supported by the lack of trans-synaptic 2-AG signaling in mice lacking sn-1-diacylglycerol lipases (DAGLs), synthesizing 2-AG. Nevertheless, how far endocannabinoids can spread extracellularly to evoke physiological responses at CB₁ cannabinoid receptors (CB₁Rs) remains poorly understood. Here, we first show that cholinergic innervation of CA1 pyramidal cells of the hippocampus is sensitive to the genetic disruption of 2-AG signaling in DAGLα null mice. Next, we exploit a hybrid COS-7-cholinergic neuron co-culture system to demonstrate that heterologous DAGLα overexpression spherically excludes cholinergic growth cones from 2-AG-rich extracellular environments, and minimizes cell-cell contact in vitro. CB₁R-mediated exclusion responses lasted 3 days, indicating sustained spherical 2-AG availability. Overall, these data suggest that extracellular 2-AG concentrations can be sufficient to activate CB₁Rs along discrete spherical boundaries to modulate neuronal responsiveness."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep02093"xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Doherty P."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Watanabe M."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Hobbs C."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Harkany T."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Kano M."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Sakimura K."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Hurd Y.L."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Howell F."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Alpar A."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Keimpema E."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/author | "Malenczyk K."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/pages | "2093"xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/title | "Diacylglycerol lipase alpha manipulation reveals developmental roles for intercellular endocannabinoid signaling."xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23806960 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23806960 |
| http://purl.uniprot.org/citations/23806960 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23806960 |
| http://purl.uniprot.org/uniprot/#_A0A385KNU8-mappedCitation-23806960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23806960 |
| http://purl.uniprot.org/uniprot/#_A4FU75-mappedCitation-23806960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23806960 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPD4-mappedCitation-23806960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23806960 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPY2-mappedCitation-23806960 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23806960 |