| http://purl.uniprot.org/citations/23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23807227 | http://www.w3.org/2000/01/rdf-schema#comment | "Small G proteins of the Rho family are pivotal regulators of several signaling networks. The Ras homolog family (Rho) and one of its targets, Rho-associated protein kinase (ROCK), participate in a wide variety of biological processes, including bone formation. A previous study has demonstrated that the ROCK inhibitor Y-27632 enhanced bone formation induced by recombinant human bone morphogenetic protein-2 (BMP-2) in vivo and in vitro. However, the effect of other Rho family members, such as Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division cycle 42 (Cdc42), on bone formation remains unknown. In this study, we investigated whether Rac1 also participates in BMP-2-induced osteogenesis. Expression of a dominant-negative mutant of Rac1 enhanced BMP-2-induced osteoblastic differentiation in C2C12 cells, whereas a constitutively active mutant of Rac1 attenuated that effect. Knockdown of T-lymphoma invasion and metastasis 1 (Tiam1), a Rac-specific guanine nucleotide exchange factor, enhanced BMP-2-induced alkaline phosphatase activity. Further, we demonstrated that BMP-2 stimulated Rac1 activity. These results indicate that the activation of Rac1 attenuates osteoblastic differentiation in C2C12 cells."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2013.226"xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/author | "Fujita Y."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/author | "Yoshikawa H."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/author | "Onishi M."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/pages | "e698"xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/title | "Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation."xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/23807227 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23807227 |
| http://purl.uniprot.org/citations/23807227 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23807227 |
| http://purl.uniprot.org/uniprot/#_Q8BPG5-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/#_K7Q7T7-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/#_P63001-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/#_Q3TLP8-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/#_Q9D859-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/#_Q8C4N8-mappedCitation-23807227 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/Q9D859 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/Q8C4N8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/K7Q7T7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/P63001 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23807227 |
| http://purl.uniprot.org/uniprot/Q3TLP8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23807227 |