Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23809616http://www.w3.org/2000/01/rdf-schema#comment"

Background & aims

Primary biliary cirrhosis (PBC) is an autoimmune liver disease. Genetic factors are critical in determining susceptibility to PBC. Among human leuocyte antigen (HLA) genes, an association between the DRB1*08 allele and PBC has been reported in many populations, but not in Chinese patients.

Methods

We investigated HLA-A, B, DRB1, and DQB1 alleles and haplotypes in 145 PBC patients and 500 healthy subjects. Patients were also stratified according to autoantibody features, and associations between these and HLA alleles were analyzed.

Results

Significant associations existed between HLA-DRB1*08:03 (22.1% vs. 9.0%, Pc < 0.0001, OR = 2.86), DQ2 (41.4% vs. 25.4%, Pc < 0.0001, OR = 2.07) and DQB1*06:01 (31.0% vs. 17.8%, Pc = 0.014, OR = 2.08) alleles and PBC. DRB1*08:03-DQB1*06:01 (22.1% vs. 8.2%, P < 0.0001, OR = 3.17) and DRB1*07:01-DQB1*02:02 haplotypes (28.3% vs. 17.6%, P = 0.005, OR = 1.85) were also associated with PBC susceptibility. In contrast, the DQB1*03:01 allele (21.4% vs. 39.2%, Pc < 0.0001, OR = 0.42) and DRB1*12:02-DQB1*03:01 haplotype (6.9% vs. 14.6%, P = 0.015, OR = 0.43) were significantly decreased in PBC patients compared with controls. DRB1*14:54 and DQ5(1) protected against antinuclear antibody (ANA) (OR = 0.25) and anti-gp210 antibody (OR = 0.39) production, respectively, while HLA-B*44:03 predisposed patients to anti-gp210 antibody (OR = 5.70) production.

Conclusion

These results suggest that Chinese patients with PBC have a distinct genetic background in eastern Asia, and we confirmed the role of HLA genes in determining PBC susceptibility and autoantibody features in the Chinese population."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.org/dc/terms/identifier"doi:10.1111/liv.12236"xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Zhao Y."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Sun L.M."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Liu Y.M."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Ma Y.X."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Liao H.Y."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Zhang H.P."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Zhao D.T."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/author"Yan H.P."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/date"2014"xsd:gYear
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/name"Liver Int"xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/pages"220-226"xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/title"Human leucocyte antigen alleles and haplotypes and their associations with antinuclear antibodies features in Chinese patients with primary biliary cirrhosis."xsd:string
http://purl.uniprot.org/citations/23809616http://purl.uniprot.org/core/volume"34"xsd:string
http://purl.uniprot.org/citations/23809616http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23809616
http://purl.uniprot.org/citations/23809616http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23809616
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
http://purl.uniprot.org/uniprot/#_A0A0E3DC99-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-23809616http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23809616
▶