| http://purl.uniprot.org/citations/23810557 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23810557 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the most dramatic forms of chromatin reorganization occurs during spermatogenesis, when the paternal genome is repackaged from a nucleosomal to a protamine-based structure. We assessed the role of the canonical histone chaperone CAF1 in Drosophila spermatogenesis. In this process, CAF1 does not behave as a complex, but its subunits display distinct chromatin dynamics. During histone-to-protamine replacement, CAF1-p180 dissociates from the DNA while CAF1-p75 binds and stays on as a component of sperm chromatin. Association of CAF1-p75 with the paternal genome depends on CAF1-p180 and protamines. Conversely, CAF1-p75 binds protamines and is required for their incorporation into sperm chromatin. Histone removal, however, occurs independently of CAF1 or protamines. Thus, CAF1-p180 and CAF1-p75 function in a temporal hierarchy during sperm chromatin assembly, with CAF1-p75 acting as a protamine-loading factor. These results show that CAF1 subunits mediate the assembly of two fundamentally different forms of chromatin."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.06.002"xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Verrijzer C.P."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Moshkin Y.M."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Demmers J.A."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Bezstarosti K."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Renkawitz-Pohl R."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Doyen C.M."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Rathke C."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/author | "Chalkley G.E."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/pages | "59-65"xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/title | "Subunits of the histone chaperone CAF1 also mediate assembly of protamine-based chromatin."xsd:string |
| http://purl.uniprot.org/citations/23810557 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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