| http://purl.uniprot.org/citations/23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23811404 | http://www.w3.org/2000/01/rdf-schema#comment | "Myocardin-related transcription factors (MRTFs) are robust coactivators of serum response factor (SRF). MRTFs contain three copies of the RPEL motif at their N-terminus, and they bind to monomeric globular actin (G-actin). Previous studies illustrate that G-actin binding inhibits MRTF activity by preventing the MRTFs nuclear accumulation. In the living cells, the majority of G-actin is sequestered by G-actin binding proteins that prevent spontaneous actin polymerization. Here, we demonstrate that the most abundant G-actin sequestering protein thymosin-β4 (Tβ4) was involved in the regulation of subcellular localization and activity of MRTF-A. Tβ4 competed with MRTF-A for G-actin binding; thus, interfering with G-actin-MRTF-A complex formation. Tβ4 overexpression induced the MRTF-A nuclear accumulation and activation of MRTF-SRF signaling. The activation rate of MRTF-A by the Tβ4 mutant L17A, whose affinity for G-actin is very low, was lower than that by wild-type Tβ4. In contrast, the β-actin mutant 3DA, which has a lower affinity for Tβ4, more effectively suppressed MRTF-A activity than wild-type β-actin. Furthermore, ectopic Tβ4 increased the endogenous expression of SRF-dependent actin cytoskeletal genes. Thus, Tβ4 is an important MRTF regulator that controls the G-actin-MRTFs interaction."xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.06.069"xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/author | "Hayashi K."xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/author | "Morita T."xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/pages | "331-335"xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/title | "G-actin sequestering protein thymosin-beta4 regulates the activity of myocardin-related transcription factor."xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://purl.uniprot.org/core/volume | "437"xsd:string |
| http://purl.uniprot.org/citations/23811404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23811404 |
| http://purl.uniprot.org/citations/23811404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23811404 |
| http://purl.uniprot.org/uniprot/#_A0A5F8MQ33-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_A0A668KL76-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_A2VCK8-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_B0QY84-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_A4FUJ8-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_D3YUG5-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_D3YUI2-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_P20065-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_L8E8L9-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_Q0P5N8-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_Q0P5P4-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_Q0P5Q0-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |
| http://purl.uniprot.org/uniprot/#_Q0P5T0-mappedCitation-23811404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23811404 |