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| http://purl.uniprot.org/citations/23812722 | http://www.w3.org/2000/01/rdf-schema#comment | "Translocation of messenger and transfer RNA (mRNA and tRNA) through the ribosome is a crucial step in protein synthesis, whose mechanism is not yet understood. The crystal structures of three Thermus ribosome-tRNA-mRNA-EF-G complexes trapped with β,γ-imidoguanosine 5'-triphosphate (GDPNP) or fusidic acid reveal conformational changes occurring during intermediate states of translocation, including large-scale rotation of the 30S subunit head and body. In all complexes, the tRNA acceptor ends occupy the 50S subunit E site, while their anticodon stem loops move with the head of the 30S subunit to positions between the P and E sites, forming chimeric intermediate states. Two universally conserved bases of 16S ribosomal RNA that intercalate between bases of the mRNA may act as "pawls" of a translocational ratchet. These findings provide new insights into the molecular mechanism of ribosomal translocation."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1236086"xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/author | "Noller H.F."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/author | "Lancaster L."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/author | "Donohue J.P."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/pages | "1236086"xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/title | "Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation."xsd:string |
| http://purl.uniprot.org/citations/23812722 | http://purl.uniprot.org/core/volume | "340"xsd:string |
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