| http://purl.uniprot.org/citations/23817146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23817146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23817146 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysregulation of eating behavior can lead to obesity, which affects 10% of the adult population worldwide and accounts for nearly 3 million deaths every year. Despite this burden on society, we currently lack effective pharmacological treatment options to regulate appetite. We used Drosophila melanogaster larvae to develop a high-throughput whole organism screen for drugs that modulate food intake. In a screen of 3630 small molecules, we identified the serotonin (5-hydroxytryptamine or 5-HT) receptor antagonist metitepine as a potent anorectic drug. Using cell-based assays we show that metitepine is an antagonist of all five Drosophila 5-HT receptors. We screened fly mutants for each of these receptors and found that serotonin receptor 5-HT2A is the sole molecular target for feeding inhibition by metitepine. These results highlight the conservation of molecular mechanisms controlling appetite and provide a method for unbiased whole-organism drug screens to identify novel drugs and molecular pathways modulating food intake."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep02120"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Rao Y."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Vosshall L.B."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Vosshall L.B."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Conway S."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Conway S."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Gasque G."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/author | "Gasque G."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/name | "Sci. Rep."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/pages | "SREP02120"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/pages | "srep02120"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/title | "Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/title | "Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target."xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/23817146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23817146 |