| http://purl.uniprot.org/citations/23817491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23817491 | http://www.w3.org/2000/01/rdf-schema#comment | "A 3.7-Mb region of rat chromosome 13 (45.2-49.0 Mb) affects blood pressure (BP) in females only, indicating the presence of sex-specific BP loci in close proximity to the Renin locus. In the present study, we used a series of Dahl salt-sensitive/Mcwi-13 Brown Norway congenic rat strains to further resolve BP loci within this region. We identified 3 BP loci affecting female rats only, of which the 2 smaller loci (line9BP3 and line9BP4) were functionally characterized by sequence and expression analysis. Compared with SS (SS/HsdMcwiCrl), the presence of a 591-kb region of BN (BN/NHsdMcwi) chromosome 13 (line9BP3) significantly lowered BP by 21 mm Hg on an 8% NaCl diet (153 ± 7 versus 174 ± 5 mm Hg; P<0.001). Unexpectedly, the addition of 23 kb of Brown Norway chromosome 13 (line9BP4) completely erased the female-specific BP protection on 8% NaCl diet, suggesting that BN hypertensive allele(s) reside in this region. The congenic interval of the protective line 9F strain contains 3 genes (Optc, Prelp, and Fmod), and the hypertensive line 9E contains 1 additional gene (Btg2). Sequence analysis of the 2 BP loci revealed a total of 282 intergenic variants, with no coding variants. Analysis of gene expression by quantitative real-time polymerase chain reaction revealed strain- and sex-specific differences in Prelp, Fmod, and Btg2 expression, implicating these as novel candidate genes for female-specific hypertension."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.113.01708"xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Jacob H.J."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Xiao B."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Moreno C."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Nunez L."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Greene A.S."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Flister M.J."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/author | "Hoffman M.J."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/pages | "557-563"xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/title | "Female-specific hypertension loci on rat chromosome 13."xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/23817491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23817491 |
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| http://purl.uniprot.org/uniprot/#_Q9EQP5-mappedCitation-23817491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23817491 |