| http://purl.uniprot.org/citations/23821302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23821302 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuroblastoma (NB), originating from neural crest cells, is the most common extracranial tumor of childhood. Retinoic acid (RA) which is the biological active form of vitamin A regulates differentiation of NB cells, and RA derivatives have been used for NB treatment. PPARα (peroxisome proliferator-activated receptor) plays an important role in the oxidation of fatty acids, carcinogenesis, and differentiation. URG4/URGCP gene is a proto-oncogene and that overexpression of URG4/URGCP is associated with metastasis and tumor recurrence in osteosarcoma. It has been known that URG4/URGCP gene is an overexpressed gene in hepatocellular carcinoma and gastric cancers. This study aims to detect gene expression patterns of PPARα and URG4/URGCP genes in SH-SY5Y NB cell line after RA treatment. Expressions levels of PPARα and URG4/URGCP genes were analyzed after RA treatment for reducing differentiation in SH-SY5Y NB cell line. To induce differentiation, the cells were treated with 10 μM RA in the dark for 3-10 days. Gene expression of URG4/URGCP and PPARα genes were presented as the yield of polymerase chain reaction (PCR) products from target genes compared with the yield of PCR products from the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. SH-SY5Y cells possess small processes in an undifferentiated state, and after treatment with RA, the cells developed long neurites, resembling a neuronal phenotype. PPARα gene expression increased in RA-treated groups; URG4/URGCP gene expression decreased in SH-SY5Y cells after RA treatment compared with that in the control cells. NB cell differentiation might associate with PPARα and URG4/URGCP gene expression profile after RA treatment."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-013-0970-1"xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Gunduz C."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Satiroglu-Tufan N.L."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Avci C.B."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Dodurga Y."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Caglar H.O."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Gundogdu G."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/author | "Kucukatay V."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/pages | "3853-3857"xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/title | "Regulation of URG4/URGCP and PPARalpha gene expressions after retinoic acid treatment in neuroblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://purl.uniprot.org/core/volume | "34"xsd:string |
| http://purl.uniprot.org/citations/23821302 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23821302 |
| http://purl.uniprot.org/citations/23821302 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23821302 |
| http://purl.uniprot.org/uniprot/#_B7Z7T1-mappedCitation-23821302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23821302 |
| http://purl.uniprot.org/uniprot/#_B2RAT5-mappedCitation-23821302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23821302 |
| http://purl.uniprot.org/uniprot/#_Q8TCY9-mappedCitation-23821302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23821302 |
| http://purl.uniprot.org/uniprot/B2RAT5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23821302 |
| http://purl.uniprot.org/uniprot/Q8TCY9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23821302 |
| http://purl.uniprot.org/uniprot/B7Z7T1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23821302 |