| http://purl.uniprot.org/citations/23823476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23823476 | http://www.w3.org/2000/01/rdf-schema#comment | "Sterol regulatory element-binding proteins (SREBPs) have evolved as a focal point for linking lipid synthesis with other pathways that regulate cell growth and survival. Here, we have uncovered a polycistrionic microRNA (miRNA) locus that is activated directly by SREBP-2. Two of the encoded miRNAs, miR-182 and miR-96, negatively regulate the expression of Fbxw7 and Insig-2, respectively, and both are known to negatively affect nuclear SREBP accumulation. Direct manipulation of this miRNA pathway alters nuclear SREBP levels and endogenous lipid synthesis. Thus, we have uncovered a mechanism for the regulation of intracellular lipid metabolism mediated by the concerted action of a pair of miRNAs that are expressed from the same SREBP-2-regulated miRNA locus, and each targets a different protein of the multistep pathway that regulates SREBP function. These studies reveal an miRNA "operon" analogous to the classic model for genetic control in bacterial regulatory systems."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2013.06.010"xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Moon Y.A."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Osborne T.F."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Jeon T.I."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Roqueta-Rivera M."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Phelan P.E."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Esau C.C."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Esquejo R.M."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/author | "Govindarajan S.S."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/name | "Cell Metab"xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/pages | "51-61"xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/title | "An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/23823476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23823476 |
| http://purl.uniprot.org/citations/23823476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23823476 |
| http://purl.uniprot.org/uniprot/Q969H0#attribution-9928EB0D2D180FE640D12B954D2E9B9C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23823476 |
| http://purl.uniprot.org/uniprot/Q9WTN3#attribution-7403EE1870653F714EC7978CAE4DC7A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23823476 |
| http://purl.uniprot.org/uniprot/Q3U1N2#attribution-7403EE1870653F714EC7978CAE4DC7A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23823476 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQK3-mappedCitation-23823476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23823476 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VH82-mappedCitation-23823476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23823476 |
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| http://purl.uniprot.org/uniprot/#_F6XZS9-mappedCitation-23823476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23823476 |