| http://purl.uniprot.org/citations/23823722 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23823722 | http://www.w3.org/2000/01/rdf-schema#comment | "Phosphoinositides serve crucial roles in cell physiology, ranging from cell signalling to membrane traffic. Among the seven eukaryotic phosphoinositides the best studied species is phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2), which is concentrated at the plasma membrane where, among other functions, it is required for the nucleation of endocytic clathrin-coated pits. No phosphatidylinositol other than PI(4,5)P2 has been implicated in clathrin-mediated endocytosis, whereas the subsequent endosomal stages of the endocytic pathway are dominated by phosphatidylinositol-3-phosphates(PI(3)P). How phosphatidylinositol conversion from PI(4,5)P2-positive endocytic intermediates to PI(3)P-containing endosomes is achieved is unclear. Here we show that formation of phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) by class II phosphatidylinositol-3-kinase C2α (PI(3)K C2α) spatiotemporally controls clathrin-mediated endocytosis. Depletion of PI(3,4)P2 or PI(3)K C2α impairs the maturation of late-stage clathrin-coated pits before fission. Timed formation of PI(3,4)P2 by PI(3)K C2α is required for selective enrichment of the BAR domain protein SNX9 at late-stage endocytic intermediates. These findings provide a mechanistic framework for the role of PI(3,4)P2 in endocytosis and unravel a novel discrete function of PI(3,4)P2 in a central cell physiological process."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature12360"xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Hirsch E."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Muller R."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Ullrich A."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Lampe A."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Haucke V."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Schmoranzer J."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Krauss M."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Puchkov D."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Schultz C."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Gulluni F."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Noe F."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Posor Y."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Zarbakhsh S."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Eichhorn-Gruenig M."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/author | "Schoneberg J."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/pages | "233-237"xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/title | "Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate."xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://purl.uniprot.org/core/volume | "499"xsd:string |
| http://purl.uniprot.org/citations/23823722 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23823722 |
| http://purl.uniprot.org/citations/23823722 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23823722 |