| http://purl.uniprot.org/citations/23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23828573 | http://www.w3.org/2000/01/rdf-schema#comment | "Transfer of type-1 helper T-conditioned (Th1-conditioned) cells promotes functional recovery with enhanced axonal remodeling after spinal cord injury (SCI). This study explored the molecular mechanisms underlying the beneficial effects of pro-inflammatory Th1-conditioned cells after SCI. The effect of Th1-conditioned cells from interferon-γ (ifn-γ) knockout mice (ifn-γ(-/-) Th1 cells) on the recovery after SCI was reduced. Transfer of Th1-conditioned cells led to the activation of microglia (MG) and macrophages (MΦs), with interleukin 10 (IL-10) upregulation. This upregulation of IL-10 was reduced when ifn-γ(-/-) Th1 cells were transferred. Intrathecal neutralization of IL-10 in the spinal cord attenuated the effects of Th1-conditioned cells. Further, IL-10 is robustly secreted from Th1-conditioned cells in an ifn-γ-dependent manner. Th1-conditioned cells from interleukin 10 knockout (il-10(-/-)) mice had no effects on recovery from SCI. These findings demonstrate that ifn-γ-dependent secretion of IL-10 from Th1 cells, as well as native MG/MΦs, is required for the promotion of motor recovery after SCI."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2013.234"xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Kubo T."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Takeda K."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Yamashita T."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Tanabe S."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Ueno M."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Naka T."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Serada S."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Ishii H."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/author | "Kayama H."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/name | "Cell Death Dis"xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/pages | "e710"xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/title | "ifn-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury."xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/23828573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23828573 |
| http://purl.uniprot.org/citations/23828573 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23828573 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23828573 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23828573 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23828573 |
| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23828573 |
| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-23828573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23828573 |