| http://purl.uniprot.org/citations/23831640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23831640 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling pathways initiated by transforming growth factor-β (TGF-β) and insulin-like growth factors (IGFs) are important in osteosarcoma cell growth. We have investigated a role for endogenous IGF binding protein-3 (IGFBP-3) in mediating cross-talk between TGF-β receptor and type I IGF receptor (IGF1R) signaling pathways in MG-63 osteosarcoma cells. TGF-β1 indirectly activated the Ras/Raf/MAPK pathway and induced the expression of IGFBP-3, an important regulator of IGF1R activity. IGFBP-3 attenuated TGF-β1 activation of ERK1/2 and Akt in MG-63 cells, and inhibited TGF-β1-induced cell cycle progression and proliferation. This effect of IGFBP-3 was blocked by inhibiting IGF1R signaling. TGF-β1 phosphorylated Smad2 on the non-receptor substrate sites (Ser245/250/255). Blocking the TGF-β1-induced expression of IGFBP-3 enhanced pSmad2(Ser245/250/255) and increased its nuclear accumulation. These results suggest an important role for TGF-β1 in osteosarcoma cell growth, with the induction of IGFBP-3 by TGF-β1 serving in a negative-feedback loop to control cell growth by preventing activation of the IGF1R."xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2013.06.033"xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/author | "Baxter R.C."xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/author | "Schedlich L.J."xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/author | "Yenson V.M."xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/pages | "56-64"xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/title | "TGF-beta-induced expression of IGFBP-3 regulates IGF1R signaling in human osteosarcoma cells."xsd:string |
| http://purl.uniprot.org/citations/23831640 | http://purl.uniprot.org/core/volume | "377"xsd:string |
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