| http://purl.uniprot.org/citations/23836061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23836061 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23836061 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation of self from nonself is indispensable for maintaining B cell tolerance in peripheral tissues. CD22 and Siglec-G (sialic acid-binding Ig-like lectin G) are two inhibitory coreceptors of the BCR that are implicated in maintenance of tolerance to self Ags. Enforced ligation of CD22 and the BCR by a nanoparticle displaying both Ag and CD22 ligands induces a tolerogenic circuit resulting in apoptosis of the Ag-reactive B cell. Whether Siglec-G also has this property has not been investigated in large part owing to the lack of a selective Siglec-G ligand. In this article, we report the development of a selective high-affinity ligand for Siglec-G and its application as a chemical tool to investigate the tolerogenic potential of Siglec-G. We find that liposomal nanoparticles decorated with Ag and Siglec-G ligand inhibit BCR signaling in both B1 and B2 B cells compared with liposomes displaying Ag alone. Not only is inhibition of B cell activation observed by ligating the BCR with Siglec-G, but robust tolerance toward T-independent and T-dependent Ags is also induced in mice. The ability of Siglec-G to inhibit B cell activation equally in both B1 and B2 subsets is consistent with our observation that Siglec-G is expressed at a relatively constant level throughout numerous B cell subsets. These results suggest that Siglec-G may contribute to maintenance of B cell tolerance toward self Ags in various B cell compartments."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300921"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300921"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Paulson J.C."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Paulson J.C."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Macauley M.S."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Macauley M.S."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Kawasaki N."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Kawasaki N."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Pfrengle F."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/author | "Pfrengle F."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/pages | "1724-1731"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/pages | "1724-1731"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/title | "Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/title | "Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22."xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/23836061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23836061 |
| http://purl.uniprot.org/citations/23836061 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23836061 |