| http://purl.uniprot.org/citations/23836881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23836881 | http://www.w3.org/2000/01/rdf-schema#comment | "V(D)J recombination is initiated by the RAG endonuclease, which introduces DNA double-strand breaks (DSBs) at the border between two recombining gene segments, generating two hairpin-sealed coding ends and two blunt signal ends. ATM and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are serine-threonine kinases that orchestrate the cellular responses to DNA DSBs. During V(D)J recombination, ATM and DNA-PKcs have unique functions in the repair of coding DNA ends. ATM deficiency leads to instability of postcleavage complexes and the loss of coding ends from these complexes. DNA-PKcs deficiency leads to a nearly complete block in coding join formation, as DNA-PKcs is required to activate Artemis, the endonuclease that opens hairpin-sealed coding ends. In contrast to loss of DNA-PKcs protein, here we show that inhibition of DNA-PKcs kinase activity has no effect on coding join formation when ATM is present and its kinase activity is intact. The ability of ATM to compensate for DNA-PKcs kinase activity depends on the integrity of three threonines in DNA-PKcs that are phosphorylation targets of ATM, suggesting that ATM can modulate DNA-PKcs activity through direct phosphorylation of DNA-PKcs. Mutation of these threonine residues to alanine (DNA-PKcs(3A)) renders DNA-PKcs dependent on its intrinsic kinase activity during coding end joining, at a step downstream of opening hairpin-sealed coding ends. Thus, DNA-PKcs has critical functions in coding end joining beyond promoting Artemis endonuclease activity, and these functions can be regulated redundantly by the kinase activity of either ATM or DNA-PKcs."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00308-13"xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "George R."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Hammel M."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Sleckman B.P."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Lee B.S."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Daniel J.A."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Dorsett Y."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Bassing C.H."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Chen B.P."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Oltz E.M."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Callen E."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Osipovich O."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Lees-Miller S."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Gapud E.J."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/author | "Bredemeyer A."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/pages | "3568-3579"xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/title | "Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination."xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23836881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23836881 |