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| http://purl.uniprot.org/citations/23836932 | http://www.w3.org/2000/01/rdf-schema#comment | "Distinct PSD-95 clusters are primary landmarks of postsynaptic densities (PSDs), which are specialized membrane regions for synapses. However, the mechanism that defines the locations of PSD-95 clusters and whether or how they are reorganized inside individual dendritic spines remains controversial. Because palmitoylation regulates PSD-95 membrane targeting, we combined a conformation-specific recombinant antibody against palmitoylated PSD-95 with live-cell super-resolution imaging and discovered subsynaptic nanodomains composed of palmitoylated PSD-95 that serve as elementary units of the PSD. PSD-95 in nanodomains underwent continuous de/repalmitoylation cycles driven by local palmitoylating activity, ensuring the maintenance of compartmentalized PSD-95 clusters within individual spines. Plasma membrane targeting of DHHC2 palmitoyltransferase rapidly recruited PSD-95 to the plasma membrane and proved essential for postsynaptic nanodomain formation. Furthermore, changes in synaptic activity rapidly reorganized PSD-95 nano-architecture through plasma membrane-inserted DHHC2. Thus, the first genetically encoded antibody sensitive to palmitoylation reveals an instructive role of local palmitoylation machinery in creating activity-responsive PSD-95 nanodomains, contributing to the PSD (re)organization."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201302071"xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Fukata M."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Fukata Y."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Dimitrov A."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Perez F."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Vielemeyer O."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/author | "Boncompain G."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/pages | "145-161"xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/title | "Local palmitoylation cycles define activity-regulated postsynaptic subdomains."xsd:string |
| http://purl.uniprot.org/citations/23836932 | http://purl.uniprot.org/core/volume | "202"xsd:string |
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