| http://purl.uniprot.org/citations/23837438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23837438 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms of interstitial lung disease (ILD) remain incompletely understood, although recent observations have suggested an important contribution by IL-33. Substantial elevations in IL-33 expression were found in the lungs of patients with idiopathic pulmonary fibrosis and scleroderma lung disease, as well as in the bleomycin injury mouse model. Most of the observed IL-33 expression was intracellular and intranuclear, suggesting involvement of the full-length (fl) protein, but not of the proteolytically processed mature IL-33 cytokine. The effects of flIL-33 on mouse lungs were assessed independently and in combination with bleomycin injury, using recombinant adenovirus-mediated gene delivery. Bleomycin-induced changes were not affected by gene deficiency of the IL-33 receptor T1/ST2. Combined flIL-33 expression and bleomycin injury exerted a synergistic effect on pulmonary lymphocyte and collagen accumulation, which could be explained by synergistic regulation of the cytokines transforming growth factor-β, IL-6, monocyte chemotactic protein-1, macrophage inflammatory protein\x{2013}1α, and tumor necrosis factor-α. By contrast, no increase in the levels of the Th2 cytokines IL-4, IL-5, or IL-13 was evident. Moreover, flIL-33 was found to increase the expression of several heat shock proteins (HSPs) significantly, and in particular HSP70, which is known to be associated with ILD. Thus, flIL-33 is a synergistic proinflammatory and profibrotic regulator that acts by stimulating the expression of several non-Th2 cytokines, and activates the expression of HSP70."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2013-0093oc"xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Atamas S.P."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Hasday J.D."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Luzina I.G."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Burke A.P."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Lockatell V."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Todd N.W."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Kang P.H."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Kopach P."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/author | "Nagarsekar A."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/pages | "999-1008"xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/title | "Interleukin-33 potentiates bleomycin-induced lung injury."xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23837438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23837438 |
| http://purl.uniprot.org/citations/23837438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23837438 |
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| http://purl.uniprot.org/uniprot/#_E9M2E8-mappedCitation-23837438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23837438 |
| http://purl.uniprot.org/uniprot/#_H3BLN5-mappedCitation-23837438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23837438 |
| http://purl.uniprot.org/uniprot/#_H3BKB5-mappedCitation-23837438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23837438 |
| http://purl.uniprot.org/uniprot/#_Q3UM53-mappedCitation-23837438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23837438 |