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| http://purl.uniprot.org/citations/23837815 | http://www.w3.org/2000/01/rdf-schema#comment | "In addition to its other roles, L-serine functions in one-carbon metabolism and is interconvertable with glycine via serine hydroxymethyltransferases. However, the transcriptional response by Saccharomyces cerevisiae to L-serine addition is markedly different from that to glycine, with L-serine acting as a nutrient source rather than one-carbon units. Following addition of excess L-serine, 743 genes showed significant expression changes. Induced functions included amino acid synthesis, some stress responses, and FeS metabolism, while ribosomal RNA processing, ribosome biogenesis and hexose transport were repressed. A co-regulated network of ten transcription factors could together control more than 90% of the induced and repressed genes forming a general response to changes induced by other amino acids or stresses and including the general amino acid control system usually activated in response to starvation for amino acids. A specific response to L-serine was induction of CHA1 encoding serine (threonine) dehydratase. L-serine addition resulted in a substantial transient increase in L-aspartate, which is, rather than L-glutamate, the major metabolite for short-term storage of ammonia derived from degradation of L-serine. L-aspartate synthesis was exclusively through mitochondrial metabolism of L-serine to pyruvate and ammonia, involving Cha1p, cytoplasmic pyruvate carboxylases Pyc1p and Pyc2p, and the cytoplasmic aspartate aminotransferase Aat2p."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.org/dc/terms/identifier | "doi:10.1111/1567-1364.12063"xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/author | "Lee J.C."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/author | "Dawes I.W."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/author | "Tsoi A."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/author | "Kornfeld G.D."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/name | "FEMS Yeast Res"xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/pages | "618-634"xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/title | "Cellular responses to L-serine in Saccharomyces cerevisiae: roles of general amino acid control, compartmentalization, and aspartate synthesis."xsd:string |
| http://purl.uniprot.org/citations/23837815 | http://purl.uniprot.org/core/volume | "13"xsd:string |
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