| http://purl.uniprot.org/citations/23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23838008 | http://www.w3.org/2000/01/rdf-schema#comment | "Lysophosphatidylethanolamine (LPE) is a lyso-type metabolite of phosphatidylethanolamine (a plasma membrane component), and its intracellular Ca(2+) ([Ca(2+)]i) increasing actions may be mediated through G-protein-coupled receptor (GPCR). However, GPCRs for lysophosphatidic acid (LPA), a structurally similar representative lipid mediator, have not been implicated in LPE-mediated activities in SK-OV3 or OVCAR-3 ovarian cancer cells or in receptor over-expression systems. In the present study, LPE-induced [Ca(2+)]i increase was observed in MDA-MB-231 cells but not in other breast cancer cell lines. In addition, LPE- and LPA-induced responses showed homologous and heterologous desensitization. Furthermore, VPC32183 and Ki16425 (antagonists of LPA1 and LPA3) inhibited LPE-induced [Ca(2+)]i increases, and knockdown of LPA1 by transfection with LPA1 siRNA completely inhibited LPE-induced [Ca(2+)]i increases. Furthermore, the involvement of CD97 (an adhesion GPCR) in the action of LPA1 in MDA-MB-231 cells was demonstrated by siRNA transfection. Pertussis toxin (a specific inhibitor of Gi/o proteins), edelfosine (an inhibitor of phospholipase C), or 2-APB (an inhibitor of IP3 receptor) completely inhibited LPE-induced [Ca(2+)]i increases, whereas HA130, an inhibitor of autotaxin/lysophospholipase D, did not. Therefore, LPE is supposed to act on LPA1-CD97/Gi/o proteins/phospholipase C/IP3/Ca(2+) rise in MDA-MB-231 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2013.07.001"xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Kang S."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Lee K.P."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Park S.J."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Bae Y.S."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Chung H.Y."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Im D.S."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/author | "Okajima F."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/pages | "2147-2154"xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/title | "Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells."xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/23838008 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23838008 |
| http://purl.uniprot.org/citations/23838008 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23838008 |
| http://purl.uniprot.org/uniprot/#_B3KUI0-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_B4DTS6-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_B4DQ18-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_B4E336-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_Q5VZX0-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_Q6GPG7-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/#_Q92633-mappedCitation-23838008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23838008 |
| http://purl.uniprot.org/uniprot/Q92633 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23838008 |