| http://purl.uniprot.org/citations/23840889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23840889 | http://www.w3.org/2000/01/rdf-schema#comment | "The Notch signaling pathway controls diverse cell-fate specification events throughout development. The versatility of this pathway to influence different aspects of development comes from its multiple levels of regulation. Upon ligand-induced Notch activation, the Notch intracellular domain (Notch-ICD) is released from the membrane and translocates to the nucleus, where it transduces Notch signals by regulating the transcription of downstream target genes. But the exact mechanism of translocation of Notch-ICD into the nucleus is not clear. Here, we implicate Importin-α3 (also known as karyopherin-α3) in the nuclear translocation of Notch-ICD in Drosophila. Our present analyses reveal that Importin-α3 can directly bind to Notch-ICD and loss of Importin-α3 function results in cytoplasmic accumulation of the Notch receptor. Using MARCM (Mosaic Analysis with a Repressible Cell Marker) technique, we demonstrate that Importin-α3 is required for nuclear localization of Notch-ICD. These results reveal that the nuclear transport of Notch-ICD is mediated by the canonical Importin-α3/Importin-β transport pathway. In addition, co-expression of both Notch-ICD and Importin-α3 displays synergistic effects on cell proliferation. Taken together, our results suggest that Importin-α3 mediated nuclear import of Notch-ICD may play important role in regulation of Notch signaling."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0068247"xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/author | "Mukherjee A."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/author | "Mishra A.K."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/author | "Mutsuddi M."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/author | "Sachan N."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/pages | "e68247"xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/title | "The Drosophila importin-alpha3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation."xsd:string |
| http://purl.uniprot.org/citations/23840889 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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