| http://purl.uniprot.org/citations/23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23844083 | http://www.w3.org/2000/01/rdf-schema#comment | "Double-stranded RNA-activated protein kinase R (PKR) is known to be upregulated by hepatitis C virus (HCV) and overexpressed in hepatocellular carcinoma (HCC). However, the precise roles of PKR in HCC with HCV infection remain unclear. Two HCV replicating cell lines (JFH-1 and H77s), generated by transfection of Huh7.5.1 cells, were used for experiments reported here. PKR expression was modulated with siRNA and a PKR expression plasmid, and cancer-related genes were assessed by real-time PCR and Western blotting; cell lines were further analyzed using a proliferation assay. Modulation of genes by PKR was also assessed in 34 human HCC specimens. Parallel changes in c-Fos and c-Jun gene expression with PKR were observed. Levels of phosphorylated c-Fos and c-Jun were upregulated by an increase of PKR, and were related to levels of phosphorylated JNK1 and Erk1/2. DNA binding activities of c-Fos and c-Jun also correlated with PKR expression, and cell proliferation was dependent on PKR-modulated c-Fos and c-Jun expression. Coordinate expression of c-Jun and PKR was confirmed in human HCC specimens with HCV infection. PKR upregulated c-Fos and c-Jun activities through activation of Erk1/2 and JNK1, respectively. These modulations resulted in HCC cell proliferation with HCV infection. These findings suggest that PKR-related proliferation pathways could be an attractive therapeutic target."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0067750"xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Abe M."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Ikeda Y."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Hiasa Y."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Chung R.T."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Onji M."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Tokumoto Y."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Matsuura B."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/author | "Hirooka M."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/pages | "e67750"xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/title | "Protein kinase R modulates c-Fos and c-Jun signaling to promote proliferation of hepatocellular carcinoma with hepatitis C virus infection."xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23844083 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23844083 |
| http://purl.uniprot.org/citations/23844083 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23844083 |
| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |
| http://purl.uniprot.org/uniprot/#_A0A7I2V2I8-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |
| http://purl.uniprot.org/uniprot/#_B4DJC7-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |
| http://purl.uniprot.org/uniprot/#_G5E9Q4-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |
| http://purl.uniprot.org/uniprot/#_P01100-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |
| http://purl.uniprot.org/uniprot/#_O75569-mappedCitation-23844083 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23844083 |